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JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors,
with some selectivity for CB2. It produces effects in animals similar to those of (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis
products such as “legal cannabis herbal incense blends” which in some countries are sold legally as “incense”, labeled “not for human consumption”.


Clinical data
Routes of
administration    Smoked, Oral
Legal status
AU: S9 (Prohibited)
CA: Schedule II
DE: Anlage II (Authorized trade only, not prescriptible)
US: Schedule I
IUPAC name[show]
CAS Number
PubChem CID
8558143 Yes
CHEMBL561013 Yes
ECHA InfoCard    100.163.574
Chemical and physical data
Formula    C24H23NO
Molar mass    341.45 g/mol
Solubility in water    hydrophobic, n/a mg/mL (20 °C)
Yes (what is this?)  (verify)
JWH018 is a full agonist of both the CB1 and CB2 cannabinoid receptors,
with a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2.
[3] JWH-018 has an EC50 of 102 nM for human CB1 receptors, and 133 nM for human CB2 receptors.
[12] JWH-018 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg,
suggesting potent cannabinoid-like activity. Buy jwh-018 online and get discreet packaging

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